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Following five consecutive screening procedures (consisting of screening the binding of peptides to glutathione Sepharose 4B beads, and screening the positive clones as GST inhibitors), the inhibitor efficiencies of all positive clones were compared

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These results were echoed in a 2013 meta-analysis of 19 clinical studies, 13 which concluded that melatonin significantly decreased sleep onset latency, increased total sleep time, and improved sleep quality over placebos